MOLECULES, MATERIALS AND MEDICINE

Our lab develops biomaterials and bioengineering concepts to solve unmet clinical needs. 

Our lab is placed within a rich scientific environment and ecosystem of Bangalore Life Sciences Cluster which consists of the Institute for Stem Cell Biology and Regenerative Medicine (inStem), National Centre for Biological Sciences (NCBS) and Centre for Cellular and Molecular Platforms (C-CAMP). This ecosystem enables fundamental discoveries and nurtures translational path. 

We are a group of highly committed individuals who seek fun in solving challenging medical problems to make an impact in patients' lives. We believe laboratory innovations should not only remain at lab-bench, but should be translatable into the clinic to help people. Thus, our ultimate goal is to develop therapeutics/strategies that can rapidly translate into the clinic. Our approach to achieving this goal is through an interactive and collaborative research with biologists, engineers, material scientists, clinicians, and entrepreneurs. 

In addition, professional development of our team members takes the priority, and this lab is dedicated to the development of next-generation chemists, material scientists, and bioengineers to work at the forefront of translational research.

More about our research vision and lab's philosophy can be read here: An interview with Praveen Vemula by Anusha

KEY PUBLICATIONS

- Jain A. et al. "Chemical fuel-driven living and transient supramolecular polymerization" Nat. Commun. 2019, 10, 450. Link

- Singh R. et. al. “Enhancement of gut barrier integrity by a microbial metabolite through the Nrf2 pathway” Nat. Commun. 2019, 10, 89 Link

- Thorat K. et al. “Prevention of pesticide-induced neuronal dysfunction and mortality with nucleophilic poly-Oxime topical gel” Sci. Adv. 2018, 4, eaau1780  Link

- Vidyanand S. et al. “The miR-124 family of microRNAs critical for regeneration of the brain and visual system in the planarian Schmidtea mediterranea” Development 2017, 144, 3211-3223  Link

- Kurbet AS. et al. “Sterile inflammation enhances ECM degradation in integrin β1 KO embryonic skin” Cell Rep. 2016, 16, 3334-47. Link

- Zhang S. et al. "An inflammation-targeting hydrogel for local delivery in inflammatory bowel disease" Sci. Transl. Med. 2015, 7, 300ra128. Link

- Gajanayake T, et al. "A single localized dose of enzyme-responsive hydrogel improves long-term survival of a vascularized composite allograft" Sci. Transl. Med. 2014, 6, 248ra110. Link

- Vemula PK. et al. “Nanoparticles reduce nickel allergy by capturing metal ions” Nat. Nanotech. 2011, 6, 291-295. Link

- Kumar A. et al. "Silver nanoparticle-embedded anti-microbial paints based on vegetable oil" Nat. Mater. 2008, 7, 236-241. Link